Karim Jerbi (Brain Dynamics and Cognition Lab, INSERM U821, Lyon, France)

The Bernstein Center Freiburg

Bernstein Seminar

Karim Jerbi

Brain Dynamics & Cognition, INSERM U821
Lyon, France

 

Large-scale brain dynamics of
perceptuo-motor behavior:
Insights from MEG and intracerebral EEG
and implications for future Brain Computer Interfaces

Abstract:
Local and long-distance neural synchonization play a key role in mediating sensorimotor behavior. Although neuroimaging studies continue to play a fundamental role in the study of large-scale perceptuo-motor networks, the fine-scale temporal and oscillatory properties of such networks need to be investigated with high (millisecond) temporal resolution. I will present data using invasive and non-invasive electrophysiological techniques that investigate oculomotor behavior and visuomotor control. First, using Magnetoencephalography (MEG) we address the role of cerebral oscillations and long-range cortico-cortical coupling in mediating continuous visuomotor control. Beyond providing direct links between cortical activity and hand movement kinematics, our data reveal task-specific modulations of large-scale parieto-frontal activations across multiple frequency bands. In a separate study, we used stereotactic-EEG (SEEG) to record directly from various brain structures in implanted epilepsy patients while they performed a delayed saccade paradigm. The unique human intracranial findings we report suggest that high frequency activity in the gamma range (60-140 Hz) and long-range coupling (in alpha/beta range) might play a fundamental role in oculomotor planning as well as in a series of intricately related neural processes such as visuomotor transformation and visuo-spatial attention. Finally, we will present our real-time brain power visualization platforms: Brain TV and Brain Ball and discuss possible implications of our findings in the context of brain computer interfaces and neurofeedback applications.

Some related Refs:

• Jerbi K, Ossandon T, Hamam CM, Senova S, Dalal S, Jung J, Minotti L, Bertrand O, Berthoz AM, Kahane P and Lachaux J-P Task-Related Gamma-Band Dynamics From an Intracerebral Perspective: Review and Implications for Surface EEG and MEG Hum Brain Mapp., 2009 Jun; 30(6):1758-71.
• Jerbi K, Lachaux J-P, N'Diaye K, Pantazis D, Leahy RM, Garnero L and Baillet S, "Neural representation of hand speed in humans revealed by MEG imaging" Proc. Nat. Acad. Sci. USA, 2007 May 1;104(18):7676-81.
• Jerbi K, Freyermuth S, Dalal SS, Kahane P, Bertrand O, Berthoz A, Lachaux J-P, Saccade Related Gamma-Band Activity in Intracerebral EEG: Dissociating Neural from Ocular Muscle Activity. Brain Topogr. 2009 Jun; 22:18-23.
• Jerbi K, Freyermuth S, Minotti L, Kahane P, Berthoz A and Lachaux J-P, Watching Brain TV and Playing Brain Ball: Exploring novel BCI strategies using real-time analysis of human intracranial data , Int Rev Neurobiol. 2009;86:159-68.
• Jerbi K and Bertrand O "Cross-frequency coupling in parieto-frontal oscillatory networks during motor imagery revealed by magnetoencephalography" in Front. Neurosci. 2009, 3, 1:3-4.
• Jerbi K, Hamam CM, Ossandon T and Dalal SS Role of Posterior Parietal Gamma Activity in Planning Prosccades and Antisccades J Neurosci, 2008 Dec 17; 28(51):13713-5.

Host: Jörn Rickert