Magnus Richardson (Warwick Systems Biology Centre, University of Warwick, Coventry, UK)

The Bernstein Center Freiburg

Bernstein Seminar

Magnus Richardson

Warwick Systems Biology Centre
University of Warwick, Coventry, UK

 

Experimentally verified neuron models and mathematical tools for their analyses

Abstract:
In this talk I will review some of the efforts we have made over the last few years to develop mathematically tractable and experimentally tested models of neocortical neurons and synapses. Using a dynamic IV curve method I will show how surprisingly accurate non-linear integrate-and-fire models can be extracted from a few tens of seconds of intracellular recording. In the context of stochastic synaptic drive, I will outline a simple method for deriving the steady-state and dynamical properties of populations and networks comprised of this class of verified model neuron. I will then go on to cover recent experimental and theoretical work on the effect of the finite amplitude of post-synaptic potentials on integration and transmission between neocortical cells.

Host: Stefan Rotter